Invention Grant
- Patent Title: Compounds and compositions as inhibitors of MEK
- Patent Title (中): 化合物和组合物作为MEK的抑制剂
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Application No.: US14451563Application Date: 2014-08-05
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Publication No.: US09227969B2Publication Date: 2016-01-05
- Inventor: Mark Gary Bock , Henrik Moebitz , Sunil Kumar Panigrahi , Ramulu Poddutoori , Susanta Samajdar
- Applicant: Mark Gary Bock , Henrik Moebitz , Sunil Kumar Panigrahi , Ramulu Poddutoori , Susanta Samajdar
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Qian Zhang
- Priority: IN2418/DEL/13 20130814; IN1686/DEL/14 20140624
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/53 ; A61K31/4745 ; A61K31/506 ; A61K31/513 ; A61K31/437 ; A61K45/06
Abstract:
The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.
Public/Granted literature
- US20150051209A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK Public/Granted day:2015-02-19
Information query
