Invention Grant
- Patent Title: Covalent inhibitors of Kras G12C
- Patent Title (中): Kras G12C的共价抑制剂
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Application No.: US14212656Application Date: 2014-03-14
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Publication No.: US09227978B2Publication Date: 2016-01-05
- Inventor: Pingda Ren , Yi Liu , Liansheng Li , Jun Feng , Tao Wu
- Applicant: Araxes Pharma LLC
- Applicant Address: US CA La Jolla
- Assignee: Araxes Pharma LLC
- Current Assignee: Araxes Pharma LLC
- Current Assignee Address: US CA La Jolla
- Agency: Seed IP Law Group PLLC
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D403/04 ; C07D487/10 ; C07D211/62 ; C07D213/64 ; C07D487/04 ; C07D295/16 ; C07D205/04 ; C07D401/04 ; C07D285/14 ; G01N33/58 ; C07D213/74 ; C07D231/40 ; C07D401/12 ; C07D237/04 ; C07D403/06 ; C07D405/06 ; C07D419/12 ; C07D471/04 ; C07D285/16 ; C07D211/56 ; C07D211/58 ; C07D211/60
Abstract:
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.
Public/Granted literature
- US20140288045A1 COVALENT INHIBITORS OF KRAS G12C Public/Granted day:2014-09-25
Information query
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