Invention Grant
US09227997B2 Composition for treating sepsis or septic shock comprising the peptide originated from the Smad6
有权
用于治疗败血症或败血性休克的组合物，其包含源自Smad6的肽
- Patent Title: Composition for treating sepsis or septic shock comprising the peptide originated from the Smad6
- Patent Title (中): 用于治疗败血症或败血性休克的组合物，其包含源自Smad6的肽
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Application No.: US13730423Application Date: 2012-12-28
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Publication No.: US09227997B2Publication Date: 2016-01-05
- Inventor: Seok Hee Park , Youn Sook Lee , Yoe Sik Bae , Seong-Jin Kim
- Applicant: Medpacto, Inc.
- Applicant Address: KR Suwon-si
- Assignee: Medpacto, Inc.
- Current Assignee: Medpacto, Inc.
- Current Assignee Address: KR Suwon-si
- Agency: NSIP Law
- Priority: KR10-2011-0144262 20111228
- Main IPC: C07K7/08
- IPC: C07K7/08 ; A61K38/10 ; C07K1/107 ; A61K47/48
Abstract:
Disclosed is a pharmaceutical composition comprising a Smad6-derived peptide as an active ingredient. Having ability to specifically bind to Pellino-1, the Smad6-derived peptide is effectively useful in the treatment of the sepsis mediated by excessively activated TLR. The peptide effectively reduces the expression of inflammatory cytokines, protects cells from sepsis-induced apoptosis, and exhibits high bacterial clearance in animal models of sepsis.
Public/Granted literature
- US20130172231A1 COMPOSITION FOR TREATING SEPSIS OR SEPTIC SHOCK COMPRISING THE PEPTIDE ORIGINATED FROM THE SMAD6 Public/Granted day:2013-07-04
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