Invention Grant
US09228005B2 Myonectin (CTRP15), compositions comprising same, and methods of use
有权
Myonectin（CTRP15），包含其的组合物和使用方法
- Patent Title: Myonectin (CTRP15), compositions comprising same, and methods of use
- Patent Title (中): Myonectin（CTRP15），包含其的组合物和使用方法
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Application No.: US14373685Application Date: 2013-01-24
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Publication No.: US09228005B2Publication Date: 2016-01-05
- Inventor: Guang William Wong , Marcus Michael Seldin
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Johns Hopkins Technology Transfer
- International Application: PCT/US2013/022855 WO 20130124
- International Announcement: WO2013/112663 WO 20130801
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61P3/06 ; A61K38/16 ; C07K1/00 ; C07K14/00 ; C07K17/00 ; C07K14/52 ; C07K14/775 ; A61K38/17 ; C07K14/47 ; C07K16/24
Abstract:
Disclosed is the novel myokine known as myonectin (CTRP15), an isolated nucleic acid encoding the myonectin (CTRP15) gene, and the amino acid sequence encoding the myonectin (CTRP15) protein. Methods of isolation of the nucleic acid, protein, polypeptides and methods of making antibodies to the myonectin (CTRP15) protein are provided. The use of myonectin (CTRP15) in the modulation of lipid and/or glucose metabolism, suppressing the expression of autophagy genes, inhibiting LC3 lipidation and autophagosome-dependent p62 degradation, and activating the Akt/mTOR pathway is also provided.
Public/Granted literature
- US20140371142A1 MYONECTIN (CTRP15), COMPOSITIONS COMPRISING SAME, AND METHODS OF USE Public/Granted day:2014-12-18
Information query
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