Invention Grant
- Patent Title: Lung-targeting nanobodies against pulmonary surfactant protein A and their preparation
- Patent Title (中): 肺靶向纳米抗体对肺表面活性蛋白A及其制备
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Application No.: US13957923Application Date: 2013-08-02
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Publication No.: US09228010B2Publication Date: 2016-01-05
- Inventor: Huiping Li , Shanmei Wang
- Applicant: Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Applicant Address: CN Shanghai
- Assignee: Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Current Assignee: Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Current Assignee Address: CN Shanghai
- Agency: Sheppard Mullin Richter & Hampton LLP
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/00 ; A61K9/127 ; A61K39/395 ; C12P21/08 ; C07K16/00
Abstract:
The present invention relates to pharmaceutical and medical technologies, and more particularly to novel nanobodies against pulmonary surfactant protein A (SP-A) and their preparation methods. The nanobodies of the present invention comprises an amino acid sequence having certain formula. The present invention also relates to nucleic acid sequences encoding the nanobodies, their preparation method and their applications. Immunohistochemistry and in vivo imaging show that the nanobodies of the present inventions have high lung-targeting specificity.
Public/Granted literature
- US20140314832A1 LUNG-TARGETING NANOBODIES AGAINST PULMONARY SURFACTANT PROTEIN A AND THEIR PREPARATION Public/Granted day:2014-10-23
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