Invention Grant
- Patent Title: Inducible regulatory T-cell generation for hematopoietic transplants
- Patent Title (中): 造血移植诱导调节性T细胞产生
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Application No.: US12999926Application Date: 2009-06-19
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Publication No.: US09228172B2Publication Date: 2016-01-05
- Inventor: James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
- Applicant: James L. Riley , Carl H. June , Bruce R. Blazar , Keli Hippen
- Applicant Address: US PA Philadelphia US MN Minneapolis
- Assignee: The Trustees of the University of Pennsylvania,Regents of the University of Minnesota
- Current Assignee: The Trustees of the University of Pennsylvania,Regents of the University of Minnesota
- Current Assignee Address: US PA Philadelphia US MN Minneapolis
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle; Kelly J. Morgan
- International Application: PCT/US2009/047887 WO 20090619
- International Announcement: WO2009/155477 WO 20091223
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/00 ; C12N5/02 ; C12N5/0783 ; A61K39/00 ; A61K35/12
Abstract:
The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases.
Public/Granted literature
- US20110268752A1 Inducible Regulatory T-Cell Generation for Hematopoietic Transplants Public/Granted day:2011-11-03
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