Invention Grant
US09228186B2 Methods and compositions for selecting siRNA of improved functionality
有权
用于选择改进功能的siRNA的方法和组合物
- Patent Title: Methods and compositions for selecting siRNA of improved functionality
- Patent Title (中): 用于选择改进功能的siRNA的方法和组合物
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Application No.: US14097551Application Date: 2013-12-05
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Publication No.: US09228186B2Publication Date: 2016-01-05
- Inventor: Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
- Applicant: Thermo Fisher Scientific Inc.
- Applicant Address: US MA Waltham
- Assignee: Thermo Fisher Scientific Inc.
- Current Assignee: Thermo Fisher Scientific Inc.
- Current Assignee Address: US MA Waltham
- Agency: Fenwick & West LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/113 ; A61K31/713 ; C12N15/10 ; C12N15/11
Abstract:
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
Public/Granted literature
- US20140148362A1 Methods and Compositions for Selecting siRNA of Improved Functionality Public/Granted day:2014-05-29
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