Invention Grant
US09228202B2 Intracellular viral vector delivery method employing iron ion/viral vector composite
有权
使用铁离子/病毒载体复合物的细胞内病毒载体递送方法
- Patent Title: Intracellular viral vector delivery method employing iron ion/viral vector composite
- Patent Title (中): 使用铁离子/病毒载体复合物的细胞内病毒载体递送方法
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Application No.: US13499101Application Date: 2010-09-28
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Publication No.: US09228202B2Publication Date: 2016-01-05
- Inventor: Young Chul Sung , Sang Hoon Park , Ki Seok Park
- Applicant: Young Chul Sung , Sang Hoon Park , Ki Seok Park
- Applicant Address: KR Pohang-si, Gyeongsangbuk KR Pohang-si, Gyeongsangbuk
- Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION,BIOD CO., LTD.
- Current Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION,BIOD CO., LTD.
- Current Assignee Address: KR Pohang-si, Gyeongsangbuk KR Pohang-si, Gyeongsangbuk
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2009-0093832 20091001
- International Application: PCT/KR2010/006577 WO 20100928
- International Announcement: WO2011/040738 WO 20110407
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N15/63 ; C12N15/864 ; C12N15/861 ; C12N15/867 ; C12N15/00 ; C12N15/863
Abstract:
The present invention relates to an intracellular viral vector delivery method employing an iron ion/viral vector composite. The iron ion/viral vector composite according to the present invention is not dependent on the expression of CAR and so improves the efficiency of delivery of viral vectors and gene expression in cells of diverse types, and has an outstanding virus-neutralizing antibody escape performance, exhibits little cytotoxicity and is outstandingly stable even when subjected to iron ion processing at low concentration, and hence can be used to advantage in recombinant viral vaccine compositions.
Public/Granted literature
- US20120183573A1 INTRACELLULAR VIRAL VECTOR DELIVERY METHOD EMPLOYING IRON ION/VIRAL VECTOR COMPOSITE Public/Granted day:2012-07-19
Information query
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