Invention Grant
- Patent Title: Labeled biomolecular compositions and methods for the production and uses thereof
- Patent Title (中): 标记的生物分子组合物及其制备方法和用途
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Application No.: US13902228Application Date: 2013-05-24
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Publication No.: US09228217B2Publication Date: 2016-01-05
- Inventor: Gaetano T. Montelione , Masayori Inouye , Yuefeng Tang , Monica Roth , William Schneider
- Applicant: Rutgers, The State University of New Jersey
- Applicant Address: US NJ New Brunswick
- Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee Address: US NJ New Brunswick
- Agency: Fox Rothschild LLP
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N1/20 ; C12N15/00 ; C12P21/00 ; C12N9/22 ; C12P21/02 ; G01N33/534 ; G01N33/60 ; C12N15/63 ; G01N24/08
Abstract:
Disclosed herein is a set of E. coli single-protein production (SPP) technologies with protein NMR (SPP-NMR) for (i) using isotope-enriched membrane proteins produced with the SPP system in screening detergent conditions suitable for purification and/or three-dimensional structure analysis without the requirement for protein purification, (ii) producing 2H, 13C, 15N enriched proteins suitable for high throughput and membrane protein NMR studies, and (iii) labeling with 13C—15N specific peptide bonds in proteins (referred to herein as SPP-PBL).
Public/Granted literature
- US20140011228A1 Labeled Biomolecular Compositions and Methods for the Production and Uses Thereof Public/Granted day:2014-01-09
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