Systems, methods, and other embodiments associated with wake-on-frame mechanisms are described. According to one embodiment, an apparatus includes a packet source configured to send packets to a frame processing device and a wake-on-frame mechanism that is selectable by the frame processing device between an enabled state and a disabled state. If the wake-on-frame mechanism is in the enabled state, a packet source that has a frame to send to the frame processing device sends a wake signal to the frame processing device prior to sending the packet. The packet source sends the packet to the frame processing device after receiving a ready signal from the frame processing device.