A system and method for synchronized operation of touch device has a mobile touch device which includes a USB transmission interface and a touch screen and an electronic facility host. The USB transmission interface connects to the USB interface of the electronic facility host and synchronizes image displaying, synchronized keyboard operation, and cursor operation so an image of the touch screen of the mobile touch device synchronously opens an image displaying zone on the display device of the electronic facility host and the keyboard and the cursor device directly simulate and synchronously operate touch display operation functions of the mobile touch device in the image displaying zone, operation of file duplication, writing, deletion, and edition between the facility host and the mobile touch device with at least one window of the operation platform of the electronic facility host.