Certain examples provide systems and methods to determine client compatibility. An example method includes receiving a request at an image viewer from a client browser for display of medical image data. The example method includes providing a temporary view to the client browser in response to the request. The example method includes determining client compatibility with the viewer and an associated server in the background at a client device executing the client browser while the temporary view is displayed at the client browser. The example method includes requesting the image data from the server based on the client compatibility determination. The example method includes rendering the image data and providing to the client browser based on the client compatibility determination, the rendering and presentation of the image data modified to enable or disable capability of at least one of the viewer and the server based on the client compatibility determination.