Preservation and reuse of intermediate data generated in a render setup graph for computer animation is disclosed. A processing node in the graph can generate intermediate data and, rather than send it directly to a downstream node in the graph, preserve it for reuse during subsequent processing. As a result, a downstream processing node can reuse the preserved intermediate data, rather than wait while the intermediate data is generated by the processing node in realtime. An intermediate data file management module can manage this process by storing the generated intermediate data in a file for preservation, retrieving the stored intermediate data from the file for reuse, optimizing the file storage location for speed and efficiency, and facilitating sharing of the intermediate data during collaboration between users.