Disclosed are a method and a system for updating a multi-frequency band pre-distortion coefficient lookup table, in order to solve the problems that the calculation complexity is high. Wherein, the method comprises: collecting a first frequency band reference signal and a first frequency band feedback signal, a second frequency band reference signal and a second frequency band feedback signal; calculating a first frequency band pre-distortion coefficient and a second frequency band pre-distortion coefficient; performing phase calibration on the first frequency band pre-distortion coefficient and the second frequency band pre-distortion coefficient, respectively; and updating a first lookup table according to the first frequency band pre-distortion coefficient performed the phase calibration, and updating a second lookup table according to the second frequency band pre-distortion coefficient performed the phase calibration.