A method of transmitting a random access response signal in a wireless communication system is disclosed. The method includes transmitting a random access preamble to a base station, receiving a random access response included in a data region of a specific subframe from the base station, and transmitting an uplink message to the base station based on uplink grant included in the random access response. If the data region is set to be transmitted through multiple layers based on a UE-specific reference signal and the specific subframe is a Multicast Broadcast Single Frequency Network (MBSFN) subframe, the data region is demodulated based on the UE-specific reference signal on the assumption that the data region is transmitted via a predetermined antenna port using a single-antenna transmission scheme.