An acoustic physiological monitoring system and method wherein the usability for physiological monitoring of time segments of an acoustic signal recording body sounds is determined using frequency analysis. A time segment of the acoustic signal is filtered into a target portion in a target frequency band and a non-target portion in a non-target frequency band. Energies of the target portion and the non-target portion are computed. A usability indicator for the time segment is computed using the energies. The usability of the time segment is determined using the usability indicator. A physiological parameter estimate is selectively calculated using the time segment based on the usability of the time segment. Finally, information based on the physiological parameter estimate is outputted.