A method for extracting a tissue sample is provided, including the steps of inserting a catheter into a bodily cavity, the catheter having a sampling chamber, a movable cover, and an actuation mechanism for actuating the cover, positioning the sampling chamber next to tissue to be sampled, providing a fluid to the actuation mechanism to open the cover, supplying a vacuum to draw tissue sample into the sampling chamber and to close the cover, and withdrawing the catheter from the bodily cavity. Catheter forceps for obtaining a tissue sample are also provided, including a catheter, a sampling chamber positioned at a distal end of the catheter and having a movable cover, and an actuation mechanism for moving the movable cover to an opened position by providing a fluid to the actuation mechanism and to a closed position by providing a vacuum to the actuation mechanism.