Invention Grant
- Patent Title: Orally administrable solid pharmaceutical composition and a process thereof
- Patent Title (中): 口服给药固体药物组合物及其制备方法
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Application No.: US12682825Application Date: 2008-10-16
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Publication No.: US09241908B2Publication Date: 2016-01-26
- Inventor: Anand Khedkar , Sharath Kumar Mallapura Rangappa , Ramesh Subramani , Nitesh Dave , Devesh Radhakrishnan , Sundaresh Shankar , Sudheer Chivukula , Ranjith Ramakrishna , Shanmugam Thandava Murthy , Harish Venkatraman Pai , Nilanjan Sengupta , Ramakrishnan Melarkode , Harish Iyer
- Applicant: Anand Khedkar , Sharath Kumar Mallapura Rangappa , Ramesh Subramani , Nitesh Dave , Devesh Radhakrishnan , Sundaresh Shankar , Sudheer Chivukula , Ranjith Ramakrishna , Shanmugam Thandava Murthy , Harish Venkatraman Pai , Nilanjan Sengupta , Ramakrishnan Melarkode , Harish Iyer
- Applicant Address: IN
- Assignee: BIOCON LIMITED
- Current Assignee: BIOCON LIMITED
- Current Assignee Address: IN
- Agency: Moore & Van Allen, PLLC
- Agent Marianne Fuierer
- Priority: IN02340/CHE/2007 20071016; IN00714/CHE/2008 20080324
- International Application: PCT/IN2008/000683 WO 20081016
- International Announcement: WO2009/050738 WO 20090423
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K9/16 ; A61K38/28 ; A61K47/48

Abstract:
The invention relates to improvised pharmaceutical compositions permitting ingestion via oral delivery of proteins/peptides or their conjugates, and/or cation-insulin conjugate complexes demonstrating desirable pharmacokinetic profiles and potency in efficacy models of diabetes in dogs and humans. A preferred formulation comprises 0.01%-20% w/w of insulin, insulin compound conjugates and/or cation insulin conjugates, 10%-60% w/w of one or more fatty acid components selected from saturated or unsaturated C4-C12 fatty acids and/or salts of such fatty acids and additionally contains optimal amounts of other pharmaceutically suitable polymer excipients which permit improved solubility, dissolution rate and effective bioavailability of poorly water soluble compositions and consistent in-vivo release profiles upon scalability during manufacture. A further aspect of the invention features the process of preparing the aforesaid formulations.
Public/Granted literature
- US20100285143A1 ORALLY ADMINISTERABLE SOLID PHARMACEUTICAL COMPOSITION AND A PROCESS THEREOF Public/Granted day:2010-11-11
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