Invention Grant
US09241913B2 Polysialic acid-based N-trimethyl chitosan gel nanoparticles for systemic drug delivery
有权
用于全身药物递送的聚唾液酸N-三甲基壳聚糖凝胶纳米颗粒
- Patent Title: Polysialic acid-based N-trimethyl chitosan gel nanoparticles for systemic drug delivery
- Patent Title (中): 用于全身药物递送的聚唾液酸N-三甲基壳聚糖凝胶纳米颗粒
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Application No.: US13474749Application Date: 2012-05-18
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Publication No.: US09241913B2Publication Date: 2016-01-26
- Inventor: Rebecca A. Bader
- Applicant: Rebecca A. Bader
- Applicant Address: US NY Syracuse
- Assignee: Syracuse University
- Current Assignee: Syracuse University
- Current Assignee Address: US NY Syracuse
- Agency: Bond Schoeneck & King, PLLC
- Agent David L. Nocilly; George R. McGuire
- Main IPC: A61K31/726
- IPC: A61K31/726 ; A61K9/51 ; A61K31/519 ; B82Y30/00
Abstract:
Gel nanoparticles for encapsulating and delivering a pharmaceutical compound to a patient. The nanoparticles are formed from N-trimethyl chitosan and polysialic acid, preferably in the presence of sodium tripolyphosphate. A ratio of polysialic acid to N-trimethyl chitosan of about 0.5 to 1 produces nanoparticles having diameter of about 100 nm (plus or minus 25 nm) and a zeta potential above 30 milivolts that can stability contain a pharmaceutical compound, such as methotrexate, for delivery to a patient.
Public/Granted literature
- US20120294904A1 POLYSIALIC ACID-BASED N-TRIMETHYL CHITOSAN GEL NANOPARTICLES FOR SYSTEMIC DRUG DELIVERY Public/Granted day:2012-11-22
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