Invention Grant
- Patent Title: IRE-1α inhibitors
- Patent Title (中): IRE-1α抑制剂
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Application No.: US14078792Application Date: 2013-11-13
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Publication No.: US09241942B2Publication Date: 2016-01-26
- Inventor: John Bruce Patterson , David Gregory Lonergan , Gary A. Flynn , Qingping Zeng , Peter V. Pallai
- Applicant: MannKind Corporation
- Applicant Address: US CA Valencia
- Assignee: MannKind Corporation
- Current Assignee: MannKind Corporation
- Current Assignee Address: US CA Valencia
- Agency: Banner & Witcoff, Ltd.
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07C47/55 ; C07C47/565 ; C07C47/575 ; C07D213/64 ; C07D213/69 ; C07D213/74 ; C07D217/16 ; C07D231/12 ; C07D239/26 ; C07D239/54 ; C07D261/08 ; C07D277/34 ; C07D295/192 ; C07D307/80 ; C07D317/54 ; C07D319/18 ; C07D321/10 ; C07D333/22 ; C07D333/58 ; C07D417/10 ; A61K31/11 ; A61K31/135 ; A61K31/192 ; A61K31/357 ; A61K31/381 ; A61K31/505 ; A61K31/5375 ; C07C65/30 ; C07C205/44 ; C07D295/125
Abstract:
Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Public/Granted literature
- US20140080832A1 IRE-1alpha INHIBITORS Public/Granted day:2014-03-20
Information query
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