Invention Grant
US09241993B2 Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of brain tumors
有权
支链氨基转移酶-1（BCAT1）抑制剂治疗脑肿瘤
- Patent Title: Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of brain tumors
- Patent Title (中): 支链氨基转移酶-1（BCAT1）抑制剂治疗脑肿瘤
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Application No.: US13982098Application Date: 2012-01-27
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Publication No.: US09241993B2Publication Date: 2016-01-26
- Inventor: Bernhard Radlwimmer , Martje Toenjes , Sebastian Barbus , Peter Lichter
- Applicant: Bernhard Radlwimmer , Martje Toenjes , Sebastian Barbus , Peter Lichter
- Applicant Address: DE Heidelberg
- Assignee: Deutsches Krebsforschungszentrum
- Current Assignee: Deutsches Krebsforschungszentrum
- Current Assignee Address: DE Heidelberg
- Agency: Crowell & Moring LLP
- Priority: EP11000720 20110128
- International Application: PCT/EP2012/000378 WO 20120127
- International Announcement: WO2012/100957 WO 20120802
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K39/395 ; A61K31/00 ; A61K31/7088 ; A61K31/713 ; C12N15/113 ; A61K31/196
Abstract:
Described is a compound capable of reducing or inhibiting (a) the biological activity of branched-chain-aminotranferase-1 (BCAT1) or (b) the expression of the gene encoding BCAT1 for use in a method of treating a neoplasia. A preferred compound is 1-(aminomethyl) cyclohexaneacetic acid (gabapentin).
Public/Granted literature
- US09114132B2 Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of brain tumors Public/Granted day:2015-08-25
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