Invention Grant
US09242000B2 Micro-RNAs and micro-RNA inhibitors to modulate blood vessel growth, patterning, tumor growth and malignant disease and method for making and using them
有权
微RNA和微RNA抑制剂调节血管生长，图案化，肿瘤生长和恶性疾病及其制造和使用方法
- Patent Title: Micro-RNAs and micro-RNA inhibitors to modulate blood vessel growth, patterning, tumor growth and malignant disease and method for making and using them
- Patent Title (中): 微RNA和微RNA抑制剂调节血管生长，图案化，肿瘤生长和恶性疾病及其制造和使用方法
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Application No.: US14057235Application Date: 2013-10-18
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Publication No.: US09242000B2Publication Date: 2016-01-26
- Inventor: David Cheresh , Sudarshan Anand , Sunil Advani
- Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US CA Oakland
- Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Greer Burns & Crain Ltd.
- Agent Gregory P. Einhorn
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K45/06 ; A61K31/713
Abstract:
In alternative embodiments, the invention provides compositions and methods comprising use of microRNAs and microRNA inhibitors to modulate blood vessel growth (angiogenesis), e.g., act as anti-angiogenic agents, and modulate cell and tumor microenvironment patterning, cancer cell and tumor growth and malignant disease (metastasis). In alternative embodiments, the invention provides compositions and methods that can sensitize blood vessels, e.g., tumor blood vessels, to radiation and agents and chemotherapies that cause DNA damage.
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