Invention Grant
US09242012B2 Methods for killing PSMA-expressing, taxane-resistant cancer cells
有权
杀死PSMA表达，紫杉烷耐药性癌细胞的方法
- Patent Title: Methods for killing PSMA-expressing, taxane-resistant cancer cells
- Patent Title (中): 杀死PSMA表达，紫杉烷耐药性癌细胞的方法
-
Application No.: US13030105Application Date: 2011-02-17
-
Publication No.: US09242012B2Publication Date: 2016-01-26
- Inventor: Dangshe Ma , William C. Olson , Stephen Morris , Robert J. Israel
- Applicant: Dangshe Ma , William C. Olson , Stephen Morris , Robert J. Israel
- Applicant Address: US NY Tarrytown
- Assignee: PSMA Development Company, LLC
- Current Assignee: PSMA Development Company, LLC
- Current Assignee Address: US NY Tarrytown
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K47/48
- IPC: A61K47/48 ; A61K39/395
Abstract:
Methods of killing prostate-specific membrane antigen (PSMA)-expressing, taxane-resistant cancer cells are provided. In particular, PSMA-expressing, taxane-resistant cancer cells are contacted with an antibody-drug conjugate (ADC) that comprises an antibody or antigen-binding fragment thereof that specifically binds to PSMA conjugated to monomethylauristatin norephedrine or monomethylauristatin phenylalanine.
Public/Granted literature
- US20110250216A1 METHODS FOR KILLING PSMA-EXPRESSING, TAXANE-RESISTANT CANCER CELLS Public/Granted day:2011-10-13
Information query
