Invention Grant
US09242014B2 Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
有权
受体酪氨酸激酶样孤儿受体1（ROR1）单链Fv抗体片段缀合物及其使用方法
- Patent Title: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof
- Patent Title (中): 受体酪氨酸激酶样孤儿受体1（ROR1）单链Fv抗体片段缀合物及其使用方法
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Application No.: US13703864Application Date: 2011-06-15
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Publication No.: US09242014B2Publication Date: 2016-01-26
- Inventor: Thomas J. Kipps , Jianqiang Yu
- Applicant: Thomas J. Kipps , Jianqiang Yu
- Applicant Address: US CA Oakland
- Assignee: The Regents of The University of California
- Current Assignee: The Regents of The University of California
- Current Assignee Address: US CA Oakland
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- International Application: PCT/US2011/040595 WO 20110615
- International Announcement: WO2011/159847 WO 20111222
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K16/28 ; C07K16/40 ; C07K14/725 ; C07K14/705 ; C07K16/30 ; G01N33/574 ; C07K16/46
Abstract:
Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.
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