A seat rail for a motor vehicle seat includes a lower rail, which can be connected to a motor vehicle, and a spindle, which is arranged on the lower rail in a rotationally fixed manner by a spindle retainer. The spindle retainer is fastened to the lower rail by a fastening element extending through a fastening opening on the spindle retainer and a fastening opening on the lower rail. In order to provide a seat rail having a lower rail on which rotation of the spindle retainer is largely precluded, in particular in the event of a threaded floor connection extending through the spindle retainer, the fastening openings and/or the fastening element has a cross-section deviating from a circular shape, preferably a polygonal cross-section, in a connection section arranged in the region of the fastening openings.