A metering and mixing device is disclosed for multi-component substances, such as multi-component adhesives, which includes at least two associated cartridge accommodating devices for accommodating replaceable cartridges having individual substance components, a discharging device for disclosing (e.g., simultaneously discharging) the substance components from the cartridges through component outlets by discharging pistons that plunge into the cartridge accommodating device or cartridges, and a mixing device, which is connected to the component outlets, mixes the discharged substance components, and outputs the substance components in the mixed state. At least one discharging piston can have a thread such that the discharging piston can be driven forward by the thread when the discharging piston is rotated relative to the cartridge accommodating device.