Invention Grant
US09242982B2 Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
有权
作为潜在磷酸二酯酶3（PDE3）抑制剂的吡啶并嘧啶类衍生物及其制备方法
- Patent Title: Pyridopyrimidine based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
- Patent Title (中): 作为潜在磷酸二酯酶3（PDE3）抑制剂的吡啶并嘧啶类衍生物及其制备方法
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Application No.: US14168411Application Date: 2014-01-30
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Publication No.: US09242982B2Publication Date: 2016-01-26
- Inventor: Budde Mahendar , Saidulu Mattapally , Mettu Ravinder , Sanjay Kumar Banerjee , Vaidya Jayathirtha Rao
- Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Applicant Address: IN New Delhi
- Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- Current Assignee Address: IN New Delhi
- Agency: Abelman, Frayne & Schwab
- Priority: IN0288/DEL/2013 20130201
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D471/04 ; A61K31/519 ; A61P9/06 ; A61P9/04
Abstract:
The present invention provides compounds of formula 1 as potential phosphodiesterase3 (PDE3) inhibitory agents and a process for the preparation thereof. The derivatives of formula 1 can be employed as therapeutics in human and veterinary medicine, where they can be used, for the treatment and prophylaxis of the following diseases: heart failure, dilated cardiomyopathy, platelet inhibitors, cancer and obstructive pulmonary diseases. wherein X=H, alkyl, aryl, or heteroaryl; Y=H, alkyl, aryl, or heteroaryl; A=alkyl, alkoxy, halo or CF3
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