Invention Grant
- Patent Title: Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors
- Patent Title (中): 杂环吡唑并嘧啶类似物作为JAK抑制剂
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Application No.: US13503083Application Date: 2010-10-19
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Publication No.: US09242987B2Publication Date: 2016-01-26
- Inventor: Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
- Applicant: Nigel Ramsden , Richard John Harrison , Sally Oxenford , Kathryn Bell , Nelly Piton , Claudio Dagostin , Cyrille Broussard , Andrew Ratcliffe
- Applicant Address: GB Brentford, Middlesex
- Assignee: Cellzome Limited
- Current Assignee: Cellzome Limited
- Current Assignee Address: GB Brentford, Middlesex
- Agent Robert Steve Thomas
- Priority: EP09173535 20091020
- International Application: PCT/EP2010/065700 WO 20101019
- International Announcement: WO2011/048082 WO 20110428
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P29/00 ; A61P37/00 ; A61P37/08 ; A61P41/00 ; A61K31/541 ; A61K31/5386 ; A61K31/5377 ; A61K31/496
Abstract:
The invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
Public/Granted literature
- US20120252779A1 HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS Public/Granted day:2012-10-04
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