Invention Grant
US09242993B2 Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
有权
吗啉代取代的双环嘧啶脲或氨基甲酸酯衍生物作为mTOR抑制剂
- Patent Title: Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
- Patent Title (中): 吗啉代取代的双环嘧啶脲或氨基甲酸酯衍生物作为mTOR抑制剂
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Application No.: US14350167Application Date: 2012-10-05
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Publication No.: US09242993B2Publication Date: 2016-01-26
- Inventor: Rosemary Lynch , Andrew David Cansfield , Daniel Paul Hardy , John Thomas Feutrill , Rita Adrego , Katie Ellard , Tammy Ladduwahetty
- Applicant: CELLZOME LIMITED
- Applicant Address: GB Brentford, Middlesex
- Assignee: CELLZOME LIMITED
- Current Assignee: CELLZOME LIMITED
- Current Assignee Address: GB Brentford, Middlesex
- Agent Margaret M. Tomaska; Edward R. Gimmi
- Priority: EP11184358 20111007
- International Application: PCT/EP2012/069676 WO 20121005
- International Announcement: WO2013/050508 WO 20130411
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/5386 ; A61K31/519 ; C07D417/02 ; C07D495/04 ; C07D498/08
Abstract:
The invention relates to compounds of formula (I) wherein m, o, Ra, Rb, R1 and T1 have the meaning as cited in the description and the claims. The compounds are useful as inhibitors of mTOR for the treatment or prophylaxis of mTOR related diseases and disorders. The invention also relates to pharmaceutical compositions including the compounds, the preparation of the compounds as well as their use as medicaments.
Public/Granted literature
- US20140288066A1 MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS Public/Granted day:2014-09-25
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