Invention Grant
- Patent Title: Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
- Patent Title (中): 四环杂环化合物及其用于治疗丙型肝炎的方法
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Application No.: US14766491Application Date: 2014-02-03
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Publication No.: US09242998B2Publication Date: 2016-01-26
- Inventor: Shuwen He , Xing Dai , Anandan Palani , Ravi Nargund , Zhong Lai , Nicolas Zorn , Dong Xiao , Qun Dang , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
- Applicant: Shuwen He , Xing Dai , Anandan Palani , Ravi Nargund , Zhong Lai , Nicolas Zorn , Dong Xiao , Qun Dang , Casey C. McComas , Peng Li , Xuanjia Peng , Richard Soll
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Anna L. Cocuzzo; Alysia A. Finnegan
- Priority: CNPCT/CN2013/000130 20130207
- International Application: PCT/US2014/014365 WO 20140203
- International Announcement: WO2014/123795 WO 20140814
- Main IPC: C07D498/14
- IPC: C07D498/14 ; A61K31/5365 ; A61K31/5377 ; A61K45/06
Abstract:
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
Public/Granted literature
- US20150368265A1 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF HEPATITIS C Public/Granted day:2015-12-24
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