Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US13997484Application Date: 2011-12-21
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Publication No.: US09243020B2Publication Date: 2016-01-26
- Inventor: Ramesh Kaul , Ernest J. McEachern , Harold G. Selnick , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
- Applicant: Ramesh Kaul , Ernest J. McEachern , Harold G. Selnick , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
- Applicant Address: CA Burnaby US NJ Rahway
- Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee: Alectos Therapeutics Inc.,Merck Sharp & Dohme Corp.
- Current Assignee Address: CA Burnaby US NJ Rahway
- Agency: Clark & Elbing LLP
- Priority: WOPCT/CN2011/074569 20110524
- International Application: PCT/CA2011/001397 WO 20111221
- International Announcement: WO2012/083435 WO 20120628
- Main IPC: C08B37/00
- IPC: C08B37/00 ; C07D487/02 ; A61K31/70 ; A61K31/425 ; C07H17/00 ; C07D513/04 ; C07H9/06 ; C12Q1/34
Abstract:
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20140018309A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2014-01-16
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