Invention Grant
- Patent Title: Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof
- Patent Title (中): 重组蛋白的衍生物，粒细胞集落刺激因子的同源多聚体及其制备方法
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Application No.: US14237807Application Date: 2011-08-09
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Publication No.: US09243049B2Publication Date: 2016-01-26
- Inventor: Edita Mistiniene , Jonas Henrikas Pesliakas , Milda Pleckaityte , Gintautas Zvirblis
- Applicant: Edita Mistiniene , Jonas Henrikas Pesliakas , Milda Pleckaityte , Gintautas Zvirblis
- Applicant Address: LI Vilnius
- Assignee: UAB Profarma
- Current Assignee: UAB Profarma
- Current Assignee Address: LI Vilnius
- Agency: Lowenstein Sandler LLP
- International Application: PCT/LT2011/000009 WO 20110809
- International Announcement: WO2013/022328 WO 20130214
- Main IPC: C07K14/52
- IPC: C07K14/52 ; A61K39/00 ; C07K14/535 ; C07K14/56
Abstract:
The invention relates to derivatives of recombinant proteins, comprising homo-multimers of genetically fused recombinant biologically active protein monomer units, connected via selected peptide linker moiety; and the method of preparation thereof. Derivative of recombinant protein is preferably dimer of human granulocyte colony-stimulating factor, characterised by increased circulation time in vivo.
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