Invention Grant
US09243050B2 Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8
有权
用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
- Patent Title: Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8
- Patent Title (中): 用于TLR7和TLR8的稳定免疫调节RNA（SIMRA）化合物
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Application No.: US14284938Application Date: 2014-05-22
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Publication No.: US09243050B2Publication Date: 2016-01-26
- Inventor: Ekambar R. Kandimalla , Tao Lan , Yukui Li , Dong Yu , Daqing Wang , Mallikarjuna Putta , Sudhir Agrawal
- Applicant: Idera Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Idera Pharamaceuticals, Inc.
- Current Assignee: Idera Pharamaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph C. Zucchero; Carolyn S. Elmore, Esq.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07K14/665 ; C12N15/117 ; A61K39/00 ; A61K39/395 ; A61K31/713
Abstract:
The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.
Public/Granted literature
- US20140308300A1 STABILIZED IMMUNE MODULATORY RNA (SIMRA) COMPOUNDS FOR TLR7 AND TLR8 Public/Granted day:2014-10-16
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