Invention Grant
US09243054B2 Monoclonal antibodies having homosubtype cross-neutralization properties against influenza A viruses subtype H1
有权
具有针对甲型流感病毒亚型H1的同型亚型交叉中和特性的单克隆抗体
- Patent Title: Monoclonal antibodies having homosubtype cross-neutralization properties against influenza A viruses subtype H1
- Patent Title (中): 具有针对甲型流感病毒亚型H1的同型亚型交叉中和特性的单克隆抗体
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Application No.: US12994746Application Date: 2009-05-27
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Publication No.: US09243054B2Publication Date: 2016-01-26
- Inventor: Roberto Burioni , Massimo Clementi
- Applicant: Roberto Burioni , Massimo Clementi
- Applicant Address: IT Turin
- Assignee: POMONA RICERCA S.R.L.
- Current Assignee: POMONA RICERCA S.R.L.
- Current Assignee Address: IT Turin
- Agency: Steinfl & Bruno LLP
- Priority: ITTO2008A0398 20080527
- International Application: PCT/IB2009/052212 WO 20090527
- International Announcement: WO2009/144667 WO 20091203
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07K16/10

Abstract:
A monoclonal antibody directed against the influenza A virus is described, which is capable of binding human and animal isolates of influenza A viruses expressing the H1-subtype hemagglutinin. A preferred embodiment is the antibody designated as Fab49, which shows a neutralizing activity against a plurality of influenza A virus isolates expressing the H1-subtype hemagglutinin, including animal-derived isolates. Anti-idiotype antibodies directed against the monoclonal antibody of the invention, immunogenic or vaccine compositions comprising the monoclonal antibody of the invention are also described, as well as therapeutic, prophylactic and diagnostic applications for the monoclonal antibody of the invention. The monoclonal antibody of the invention can also be employed for testing antibody preparations to be used as vaccines.
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