Invention Grant
- Patent Title: Humanized anti-factor C3b antibodies and uses thereof
- Patent Title (中): 人源化抗因子C3b抗体及其用途
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Application No.: US14390645Application Date: 2013-04-02
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Publication No.: US09243060B2Publication Date: 2016-01-26
- Inventor: Rekha Bansal
- Applicant: NovelMed Therapeutics, Inc.
- Applicant Address: US OH Cleveland
- Assignee: Novelmed Therapeutics, Inc.
- Current Assignee: Novelmed Therapeutics, Inc.
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- International Application: PCT/US2013/034990 WO 20130402
- International Announcement: WO2013/152024 WO 20131010
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/36 ; C07K16/18
Abstract:
A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3b inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC.
Public/Granted literature
- US20150064202A1 HUMANIZED AND CHIMERIC ANTI-FACTOR C3 ANTIBODIES AND USES THEREOF Public/Granted day:2015-03-05
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