Invention Grant
US09243065B2 Polypeptide constructs including VHH directed against EGFR for intracellular delivery
有权
多肽构建体包括针对EGFR用于细胞内递送的VHH
- Patent Title: Polypeptide constructs including VHH directed against EGFR for intracellular delivery
- Patent Title (中): 多肽构建体包括针对EGFR用于细胞内递送的VHH
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Application No.: US12487684Application Date: 2009-06-19
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Publication No.: US09243065B2Publication Date: 2016-01-26
- Inventor: Karen Silence , Mark Vaeck , Paul M. P. Van Bergen En Henegouwen
- Applicant: Karen Silence , Mark Vaeck , Paul M. P. Van Bergen En Henegouwen
- Applicant Address: BE Zwijnaarde
- Assignee: Ablynx N.V.
- Current Assignee: Ablynx N.V.
- Current Assignee Address: BE Zwijnaarde
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: EP03447005 20030110; EPPCT/EP2003/006581 20030623; EPPCT/EP2003/007313 20030708
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/18 ; C07K16/24 ; C07K16/36 ; C07K16/40 ; C07K16/42 ; A61K39/00
Abstract:
The invention relates to a method suitable for administering protein therapeutic molecules orally, sublingually, topically, intravenously, subcutaneously, nasally, vaginally, rectally or by inhalation so as to avoid inactivation, by using VHH polypeptides derived from Camelidae antibodies. The invention further relates to the said therapeutic molecules. The invention further relates to a method for delivering therapeutic molecules to the interior of cells. The invention further relates to polypeptide constructs including VHH directed against EGFR.
Public/Granted literature
- US20100021459A1 POLYPEPTIDE CONSTRUCTS FOR INTRACELLULAR DELIVERY Public/Granted day:2010-01-28
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