Invention Grant
- Patent Title: Humanized and chimeric anti-factor Bb antibodies and uses thereof
- Patent Title (中): 人源化和嵌合抗因子Bb抗体及其用途
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Application No.: US14390632Application Date: 2013-04-02
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Publication No.: US09243070B2Publication Date: 2016-01-26
- Inventor: Rekha Bansal
- Applicant: NovelMed Therapeutics, Inc.
- Applicant Address: US OH Cleveland
- Assignee: Novelmed Therapeutics, Inc.
- Current Assignee: Novelmed Therapeutics, Inc.
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- International Application: PCT/US2013/034982 WO 20130402
- International Announcement: WO2013/152020 WO 20131010
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/36 ; C07K16/40 ; C07K16/18 ; A61K39/00
Abstract:
A method of inhibiting complement activation mediated by Bb inhibitors in a subject includes administering a Bb inhibitor to the subject to inhibit at least one of Bb binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC.
Public/Granted literature
- US20150093390A1 HUMANIZED AND CHIMERIC ANTI-FACTOR BB ANTIBODIES AND USES THEREOF Public/Granted day:2015-04-02
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