Invention Grant
- Patent Title: Mutant cytochrome P450 2B6 proteins and uses thereof
- Patent Title (中): 突变体细胞色素P450 2B6蛋白及其用途
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Application No.: US14115639Application Date: 2012-05-04
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Publication No.: US09243231B2Publication Date: 2016-01-26
- Inventor: Isabelle De Waziers , Walid Touati , Monique Diry , Jean-Pierre Flinois , Patrick Dansette , Philippe Beaune
- Applicant: Isabelle De Waziers , Walid Touati , Monique Diry , Jean-Pierre Flinois , Patrick Dansette , Philippe Beaune
- Applicant Address: FR Paris
- Assignee: Institut National de la Santé et de la Recherche Médicale (INSERM)
- Current Assignee: Institut National de la Santé et de la Recherche Médicale (INSERM)
- Current Assignee Address: FR Paris
- Agency: Whitham, Curtis, Christofferson & Cook, P.C.
- Priority: EP11305530 20110505
- International Application: PCT/EP2012/058219 WO 20120504
- International Announcement: WO2012/150326 WO 20121108
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K38/44 ; C07K14/47 ; C12N9/02
Abstract:
The present invention to relates mutant human cytochrome P450 2B6 (CYP2B6) proteins, and fusion proteins comprising said mutant CYP2B6 proteins. In particular, fusion proteins comprising mutant CYP2B6 and NAPDH-cytochrome P450 reductase are provided. The invention also relates to methods of treatment of cancer and the use of said proteins and fusion proteins in the treatment of cancer, in particular via virus-directed enzyme prodrug therapy.
Public/Granted literature
- US20140127180A1 MUTANT CYTOCHROME P450 2B6 PROTEINS AND USES THEREOF Public/Granted day:2014-05-08
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