Invention Grant
US09243250B2 Method of enhancing miR-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell
有权
增强miR-185表达以降低细胞中低密度脂蛋白/胆固醇积累的方法
- Patent Title: Method of enhancing miR-185 expression to reduce low density lipoprotein/cholesterol accumulation in a cell
- Patent Title (中): 增强miR-185表达以降低细胞中低密度脂蛋白/胆固醇积累的方法
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Application No.: US13919141Application Date: 2013-06-17
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Publication No.: US09243250B2Publication Date: 2016-01-26
- Inventor: Muhua Yang , Joseph T Nickels, Jr. , Weidong Liu , Christina Ann Pellicane
- Applicant: Muhua Yang , Joseph T Nickels, Jr. , Weidong Liu , Christina Ann Pellicane
- Applicant Address: US NJ Hamilton
- Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee: Medical Diagnostic Laboratories, LLC
- Current Assignee Address: US NJ Hamilton
- Agent Siu K. Lo
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; C12Q1/68
Abstract:
The present invention provides a method of quantifying miR-185 as a potential biomarker in lipid disorder or cardiovascular diseases in human. The present invention also provides a method of modulating miR-185 in regulating LDL and cholesterol metabolism in cells. The present invention has therapeutic potential in the treatment of cholesterol/LDL related cardiovascular diseases in humans.
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