Invention Grant
- Patent Title: Genes associated with posttraumatic-stress disorder (PTSD)
- Patent Title (中): 与创伤后应激障碍（PTSD）相关的基因
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Application No.: US13063696Application Date: 2009-09-14
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Publication No.: US09243293B2Publication Date: 2016-01-26
- Inventor: Florian Holsboer , Marcus Ising , Rachel Yehuda , Joseph D. Buxbaum
- Applicant: Florian Holsboer , Marcus Ising , Rachel Yehuda , Joseph D. Buxbaum
- Applicant Address: DE Munich
- Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
- Current Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
- Current Assignee Address: DE Munich
- Agency: Roberts Mlotkowski Safran & Cole, P.C.
- Priority: EP08016126.8 20080912; WOPCT/EP2009/061890 20090914
- International Application: PCT/EP2009/061890 WO 20090914
- International Announcement: WO2010/029176 WO 20100318
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/02
Abstract:
The present invention relates to a method of identifying a predisposition for developing posttraumatic stress disorder (PTSD) in a subject comprising assessing in a sample obtained from said subject the expression level of one or more genes selected from the FK506 binding protein 5 (FKBP5) gene, the signal transducer and activator of transcription (STAT5B) gene and the nuclear factor I/A (NFIA) gene, wherein a decrease in the expression level of said one or more genes as compared to the expression level of the corresponding gene(s) of a control is indicative of a predisposition for developing PTSD. Further, the invention relates to a method of identifying a compound capable of preventing or treating PTSD or capable of serving as a lead compound for developing a compound capable of preventing or treating PTSD and also to a method of selecting a therapy to prevent or treat PTSD.
Public/Granted literature
- US20120039812A1 GENES ASSOCIATED WITH POSTTRAUMATIC-STRESS DISORDER (PTSD) Public/Granted day:2012-02-16
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