Systems and methods for providing vehicle-centric collision avoidance are disclosed. An example method includes determining a first flight trajectory for a first aircraft, determining a second flight trajectory for a second aircraft, predicting a distance between the first aircraft and the second aircraft at a predicted closest point of approach based on the first and second flight trajectories, comparing the distance to a separation perimeter layer, the separation perimeter layer configured to provide a minimum separation distance from the first aircraft to the second aircraft, and altering the first flight trajectory when the distance breaches the separation perimeter layer.