A control system, components and methodologies enable control of vehicle and in-vehicle system functionality via gesture recognition. In illustrative embodiments, the control system, constituent components and methodologies determine what functionality a user wishes to control by tracking the user's gaze to identify a selected function or function set. In combination with identifying the selected function and function set, one or more sensors installed in the vehicle detect one or more user gestures initiated by a user to interact with and/or control the selected function/function set.