Controlling data storage input/output requests is described, for example, to apply a policy to an end-to-end flow of data input/output requests between at least one computing entity and at least one store. In various examples a plurality of queues are configured at one or more stages of the end-to-end flow and controlled to adhere to a policy. In examples, each stage has a control interface enabling it to receive and execute control instructions from a controller which may be centralized or distributed. For example, the control instructions comprise queuing rules and/or queue configurations. In various examples queues and queuing rules are dynamically created and revised according to feedback about any of: flow behavior, changes in policy, changes in infrastructure or other factors. In examples, high level identifiers of the flow endpoints are resolved, on a per stage basis, to low level identifiers suitable for use by the stage.