A coexistence interference mitigation method is provided. In a wireless network, a wireless device is equipped with multiple radios in the same device platform. The wireless device also has a control entity that communicates with the multiple co-located radio modules. A first radio module receives a notification from the control entity. The notification informs a critical signaling status of a second radio module co-located with the first radio module. Upon receiving the notification, the first radio module stops uplink transmission due to coexistence interference and transmits a coexistence indicator to its serving eNB. After a certain period, the first radio module receives a second notification that informs a completion status of the critical signaling of the second radio module. Upon receiving the second notification, the first radio module resumes uplink transmission and transmits a coexistence resume indicator to the eNB.