A system and method can support port multiplexing in a server environment, e.g. in a distributed data grid. The server environment can comprise a port to receive one or more request, wherein the port is adapted to be associated with different port address values and the port operates to receive one or more connection requests. Additionally, the server environment allows a plurality of sockets to utilize the different port address values to support multiplexing of sockets over the port, and a multiplexed socket provider can be used to provide the plurality of sockets.