Methods and systems to enable touch-free call origination using a communication device equipped with a microphone. The method comprises processing a first microphone signal at the device in an attempt to detect a spoken activation command potentially contained therein. Responsive to detection of a spoken activation command in the first microphone signal, the method continues by establishing a communication path between the device and a network entity to convey to the network entity a second microphone signal. Finally, the method comprises processing the second microphone signal at the network entity in an attempt to detect a call origination command potentially contained therein; and, responsive to detection of a call origination command in the second microphone signal, attempting establishment of a call in accordance with the detected call origination command. Thus, a call can be established without tactile interaction with the device and, moreover, with minimal computational load on the device.