A radiation image pickup system includes a correction coefficient calculation unit that calculates a correction coefficient using pixel output values of a plurality of pixels, and a correction unit that corrects pixel output values of a plurality of pixels using the correction coefficient. A drive control unit repeatedly resets an electric charge caused by a dark current of a plurality of pixels until a detection unit detects a start of radiation exposure. The reset operation is performed simultaneously for n rows that are not adjacent to each other, where n is an integer equal to or greater than 2. The correction coefficient calculation unit calculates the correction coefficient using pixel output values of pixels in a row subjected to the reset operation in a period from a start of radiation exposure to a start detection time and pixel output values of pixels in an adjacent row.