Invention Grant
US09247759B2 Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
有权
识别在组合物中引起苦味的苦味化合物响应的人T2R受体，以及其在测定中用于鉴定组合物中抑制（阻断）苦味的化合物及其用途的用途
- Patent Title: Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
- Patent Title (中): 识别在组合物中引起苦味的苦味化合物响应的人T2R受体，以及其在测定中用于鉴定组合物中抑制（阻断）苦味的化合物及其用途的用途
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Application No.: US13896913Application Date: 2013-05-17
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Publication No.: US09247759B2Publication Date: 2016-02-02
- Inventor: Donald S. Karanewsky , Joseph R. Fotsing , Catherine Tachdjian , Melissa Arellano
- Applicant: SENOMYX, INC.
- Applicant Address: US CA San Diego
- Assignee: Senomyx, Inc.
- Current Assignee: Senomyx, Inc.
- Current Assignee Address: US CA San Diego
- Agency: LeClairRyan a Professional Corporation
- Agent Robin L. Teskin
- Main IPC: C07D261/06
- IPC: C07D261/06 ; C07D413/14 ; A61K31/44 ; A61K31/42 ; A23L1/22 ; A23L1/226 ; A61K31/135 ; A61K31/4439 ; A61K31/485 ; A61K31/60 ; A61K31/704 ; A61K45/06 ; A23F5/46
Abstract:
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
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