A method includes, in a bi-plane interventional imaging system, moving a first C-arm supporting a first X-ray source and a first X-ray detector about first and second axes while obtaining a plurality of first X-ray attenuation data sets relating to a subject of interest; moving a second C-arm, positioned crosswise with respect to the first C-arm and supporting a second X-ray source and a second X-ray detector, about the first axis while obtaining a plurality of second X-ray attenuation data sets relating to the subject of interest; and synchronizing the movement of the first and second C-arms to avoid collision therebetween.