Invention Grant
- Patent Title: Method for improving water solubility of slightly soluble substance
- Patent Title (中): 提高微溶性物质水溶性的方法
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Application No.: US14380442Application Date: 2013-02-21
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Publication No.: US09248103B2Publication Date: 2016-02-02
- Inventor: Shuji Sakuma , Keiichiro Kikukawa , Ryosuke Miyasaka
- Applicant: Kabushiki Kaisha Sangi
- Applicant Address: JP Tokyo
- Assignee: KABUSHIKI KAISHA SANGI
- Current Assignee: KABUSHIKI KAISHA SANGI
- Current Assignee Address: JP Tokyo
- Agency: King & Spalding LLP
- Agent Kenneth H. Sonnenfeld; Margaret B. Brivanlou
- Priority: JP2012-047399 20120302
- International Application: PCT/JP2013/001000 WO 20130221
- International Announcement: WO2013/128858 WO 20130906
- Main IPC: A61K9/50
- IPC: A61K9/50 ; A01N25/26 ; A61K8/24 ; A61K8/19 ; A23L1/03 ; A61K9/16 ; A61K8/02 ; A61K31/10 ; A61K31/167 ; A61K31/18 ; A61K31/195 ; A61K31/40 ; A61K31/426 ; A61K31/4515 ; A61K31/505 ; A61K31/7048 ; B05D3/12 ; B05D5/04 ; A61K8/44 ; A61K8/46 ; A61K8/67 ; A61Q19/00 ; A01N25/00 ; A61K9/14
Abstract:
It is an object of the present invention to provide a method for improving the solubility of a poorly-soluble substance, which is capable of increasing the solubility of substantially all poorly-soluble substances. This is a method comprising coating the surface of a poorly-soluble substance particle with microparticles of a calcium compound such as calcium phosphate or calcium carbonate, and at least one selected from a pH adjuster and a surfactant, by applying mechanical energy thereto.
Public/Granted literature
- US20150010638A1 Method for Improving Water Solubility of Slightly Soluble Substance Public/Granted day:2015-01-08
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